Project leader: Prof. Dr. Andreas Pfeiffer

German Institute of Human Nutrition Potsdam-Rehbruecke
Charité - Universitätsmedizin Berlin; Experimental & Clinical Research Center (ECRC)

Goals:
Within Project C a dietary study of older propositi with moderate metabolic disorder is performed. The aim is to develop a dietary pattern, which prevents age-related civilization diseases, improves the cardiovascular functions and related biomarkers, keeps the muscle mass, and reduces liver fat as well as improving the cognition and the metabolic functions. The researchers work closely together with regional and over-regional partners from the industry, which are providing special developed food for the propositi. The nutritional study is coordinated by Prof. Pfeiffer (DIfE) of the Study Center Potsdam, in close coordination with Prof. Spranger at the Charité. The plan is to create a logistical center for the efficient storage, transportation and distribution of the foods. Every study center is to recruit 250 probands (125 intervention study / 125 controls). The intervention group will be given the NutriAct-food pattern and the control group will be given the recommendation for a healthy diet based on a usual care group. The primary endpoint of the study is changes of in the cardiovascular system, muscular strength, a tendency to fall and cognitive functions. The secondary endpoint is the long-term effect of the NutriAct-food pattern on the body fat composition, the insulin sensitivity of the liver and musculature, as well as tissue-specific metabolic responses in the skeletal muscle and subcutaneous adipose tissue.